R-N-Methyl-N-[(1R)-1-phenylethyl]-Dinaphtho[2,1-d:1',2'-f][1,3,2]dioxaphosphepin-4-aMine - Names and Identifiers
R-N-Methyl-N-[(1R)-1-phenylethyl]-Dinaphtho[2,1-d:1',2'-f][1,3,2]dioxaphosphepin-4-aMine - Physico-chemical Properties
Molecular Formula | C29H24NO2P
|
Molar Mass | 449.480121 |
Boling Point | 633.4±48.0 °C(Predicted) |
pKa | 0.32±0.20(Predicted) |
Storage Condition | 2-8 ℃, dark, nitrogen storage |
R-N-Methyl-N-[(1R)-1-phenylethyl]-Dinaphtho[2,1-d:1',2'-f][1,3,2]dioxaphosphepin-4-aMine - Introduction
R-N-Methyl-N-[(1R)-1-phenylethyl]-Dinaphtho[2,1-d:1 ',2'-f][1,3,2]dioxaphosphepin-4-aMine is a compound, also known as R-N-methyl-N-[(1R)-1-phenylethyl]-dioxo-1, 3,2, 2λ5-binaphthyl [2,1-d:1 ',2'-F][1,3,2] dioxphos -4-amine. The following is an introduction to some of its properties, uses, methods and safety information:
Nature:
-Appearance: White to yellow crystal or powdery solid
-Molecular formula: C24H23FNO2P
-Molecular weight: 407.42g/mol
-Melting point: About 167-170 ° C
-Boiling Point: Data not available
-Solubility: Soluble in organic solvents, such as chloroform, dimethyl sulfoxide
Use:
- R-N-methyl-N-[(1R)-1-phenylethyl]-dioxo-1, 3,2, 2λ5-binaphthyl [2,1-d: 1 ',2'-F][1,3,2] dioxphos -4-amine is a chiral ligand commonly used in organic synthesis, which can be used as catalyst, catalytic reactions and asymmetric synthesis.
-Due to its chiral structure, it can make the synthetic product have the required stereochemical properties, so it has certain applications in drug synthesis and other fields.
Method:
R-N-Methyl-N-[(1R)-1-phenylethyl]-dioxo-1, 3,2, 2λ5-binaphthyl [2,1-d: the preparation method of 1 ',2'-F][1,3,2] dioxophosph-4-amine may include the following steps:
1. An appropriate amount of di-methyl binaphlo [2,1-d: 1 ',2'-F][1,3,2] dioxyphosphate and an appropriate amount of (R)-N-Benzyl-N-methylethylamine is reacted in a suitable organic solvent.
2. At the reaction temperature, aerate and heat the reaction mixture.
3. Purify the product by recrystallization and other methods.
Safety Information:
About R-N-methyl-N-[(1R)-1-phenylethyl]-dioxo-1, 3,2, 2λ5-binaphthyl [2,1-d: for specific Safety information of 1 ',2'-F][1,3,2] dioxphos -4-Amine, please refer to the relevant chemical Safety Technical Manual (Material Safety Data Sheet,MSDS). Use and handle chemicals in accordance with appropriate safety practices and take appropriate personal protective measures.
Last Update:2024-04-09 21:54:55